I would say that the learning curve on being a master at clicking is long but key binding can be mastered quickly.
Personally I prefer clicking. People say that its harder to maneuver but really even in 1v1, key binders and I can go toe to toe when it comes to movement.
Using the actual abilities is much easier as I can have multiple macros set up and have every ability around me. What many people don't take into account is that there is a GCD of time to move to your next ability anyway.
After loads of practice I don't ever mess up my clicks and I don't ever have to hesitate. If you set up your bars correctly then your reaction time will be the same as key binders since it takes less time to move the mouse a few inches on screen then to move your hand a few inches. If you continue to be a clicker, I recommend having your most common abilities in the center of your bars, and everything else organized around it. You can also mix some keybinding in to replace your buffs/items, although you probably already do that.
So really they are both as equally effective when mastered, only it's quicker to master key binding (and it looks better on videos to some people).